Residency time of agonists does not affect the stability of GPCR-arrestin complexes.

Nadja MössleinLisa-Marie Geertje PohleAnneke FussMoritz Bünemann Cornelius Krasel

Published in: British journal of pharmacology (2022)

Agonist off-rates do not affect the stability of GPCR-arrestin complexes but phosphorylation patterns do. Our results imply that orthosteric agonists are not able to pharmacologically convert class A into class B GPCRs.

Keyphrases

protein kinase
medical students
drug discovery