De novo emergence of SARS-CoV-2 spike mutations in immunosuppressed patients.

Lacy M SimonsEgon A OzerStephanie GambutTaylor J DeanLi ZhangPavan BhimalliJeffrey R SchneiderJoão I MamedeMichael G IsonReem KarmaliLeo I GordonRamon Lorenzo-RedondoJudd F Hultquist

Published in: Transplant infectious disease : an official journal of the Transplantation Society (2022)

These observations demonstrate the de novo emergence of SARS-CoV-2 spike mutations with enhanced immune evasion in immunosuppressed patients with persistent infection. These data suggest one potential mechanism for the evolution of VOCs and emphasize the importance of continued efforts to develop antiviral drugs for suppression of viral replication in hospitalized settings.

Keyphrases

sars cov
end stage renal disease
respiratory syndrome coronavirus
newly diagnosed
ejection fraction
peritoneal dialysis
patient reported outcomes
quality improvement
big data
machine learning
coronavirus disease
deep learning
human health