Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.

Shaowei WangBoyang LiZhiheng CaiCristelle HugoJie LiYi SunLu QianAlan T RemaleyJulia TcwHelena C ChuiDavid A BennettZoe ArvanitakisBilal KermanHussein N Yassine

Published in: Research square (2024)

Cholesterol accumulation in APOE4 and AD induced caveolin-1 expression, which traps ABCA1 in lysosomes to activate mTORC1 pathways and induce cellular senescence. This study provided novel insights into how cholesterol accumulation in APOE4 and AD accelerates senescence.

Keyphrases

low density lipoprotein
cognitive decline
endothelial cells
dna damage
high fat diet
high glucose
stress induced
mild cognitive impairment
diabetic rats
oxidative stress
type diabetes
binding protein
drug induced
metabolic syndrome