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Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia.

Maddalena ArdissinoBuu TruongEric A W SlobArt SchuermansSatoshi YoshijiAlec P MorleyStephen BurgessFu Siong NgAntonio de MarvaoPradeep NatarajanKypros H NicolaidesLiam GazianoAdam S ButterworthMichael C Honigberg
Published in: Circulation. Genomic and precision medicine (2024)
This investigation identified multiple targetable proteins linked to cardiovascular, inflammatory, and coagulation pathways, with SERPINE2, PZP, FGF5, FES, and ANP identified as pivotal proteins with likely causal roles in the development of preeclampsia. The identification of these potential targets may guide the development of targeted therapies for preeclampsia.
Keyphrases
  • early onset
  • genome wide
  • pregnancy outcomes
  • gene expression
  • rna seq
  • emergency department
  • electronic health record