Vector Aided Microenvironment programming (VAMP): reprogramming the TME with MVA virus expressing IL-12 for effective antitumor activity.

Laura SeclìLuigia InfanteLinda NocchiMaria De LuciaGabriella CotugnoGuido LeoniElisa MicarelliIrene GarziaLidia AvalleGiulia SdrusciaFulvia TroiseSimona AlloccaGiuseppina RomanoElisa ScarselliAnna Morena D'Alise

Published in: Journal for immunotherapy of cancer (2023)

Intratumoral administration of MVA-IL-12 turns immunologically 'cold' tumors 'hot' and overcomes resistance to programmed cell death protein-1 blockade.

Keyphrases

stem cells
binding protein