Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones.
Martin Pichette DrapeauAnis TliliYassir ZaidDounia ToumminiFouad Ouazzani ChahdiJean-Marc SotiropoulosThierry OllevierMarc TailleferPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
An original metal-free procedure for the synthesis of biarylmethanes is disclosed herein. The reactions occur with high selectivity starting from aryl iodides and benzylic ketones in the presence of superbasic media (CsOH/DMSO). This procedure allows a straightforward access to a wide range of biarylmethane derivatives substituted with electron-withdrawing and -donating substituents.