Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.

Henriette O'GeenSofie L BatesSakereh S CarterKarly A NissonJulian HalmaiKyle D FinkSuhn K RhiePeggy J FarnhamDavid J Segal

Published in: Epigenetics & chromatin (2019)

These data demonstrate that targeting different combinations of histone and DNA methyltransferases is required to achieve maximal repression at different loci. Fine-tuning of targeting tools is a necessity to engineer epigenetic memory at any given locus in any given cell type.

Keyphrases

dna methylation
gene expression
genome wide
working memory
cancer therapy
genome wide association study
air pollution
electronic health record
circulating tumor
heart rate
cell free
long non coding rna
big data
drug delivery
long noncoding rna
machine learning
deep learning
data analysis