Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females.

Anke Vermehren-Schmaedick Sonali JoshiWendy WagonerMason A NorgardWilliam PackwoodParham DibaHeike MendezLev M FedorovShauna RaksheByung S Park Daniel L. Marks Aaron J Grossberg Shiuh-Wen Luoh

Published in: Endocrinology (2024)

Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.

Keyphrases

glycemic control
insulin resistance
high fat diet induced
adipose tissue
type diabetes
blood glucose
high fat diet
weight loss
metabolic syndrome
skeletal muscle
single cell
gene expression
wild type