A novel role of FoxO3a in the migration and invasion of trophoblast cells: from metabolic remodeling to transcriptional reprogramming.

Hao ChenShi-Han WangChang ChenXin-Yang YuJia-Nan ZhuToby MansellBoris NovakovicRichard SafferyPhilip N BakerTing-Li HanHua Zhang

Published in: Molecular medicine (Cambridge, Mass.) (2022)

Our results suggested novel biological roles of FoxO3a in early placental development. FoxO3a exerts an essential effect on trophoblast migration and invasion owing to the regulations of COX2, MMP9, aromatic amino acids, energy metabolism, and oxidative stress.

Keyphrases

transcription factor
amino acid
pi k akt
oxidative stress
signaling pathway
gene expression
dna damage
cell proliferation
ischemia reperfusion injury
heat shock
diabetic rats
heat stress