Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS.

Veit RothhammerJessica E KenisonZhaorong LiEmily TjonMaisa C TakenakaChun-Cheih ChaoKalil Alves de LimaDavis M BoruckiJoel KayeFrancisco J Quintana

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

Taken together, these findings suggest that AHR activation by clinically relevant AHR agonists may represent a novel therapeutic approach for the treatment of MS.

Keyphrases

multiple sclerosis
oxidative stress
mass spectrometry
blood brain barrier
mouse model
binding protein
replacement therapy