Oxidative Stress and Inflammation in SARS-CoV-2- and Chlamydia pneumoniae-Associated Cardiovascular Diseases.
Simone FilardoMarisa Di PietroFabiana DiacoSilvio RomanoRosa SessaPublished in: Biomedicines (2021)
Throughout the years, a growing number of studies have provided evidence that oxidative stress and inflammation may be involved in the pathogenesis of infectious agent-related cardiovascular diseases. Amongst the numerous respiratory pathogens, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus responsible for the global ongoing pandemic, and Chlamydia pneumoniae, a widely known intracellular obligate bacteria, seem to have an essential role in promoting reactive oxygen species and cytokine production. The present review highlights the common oxidative and inflammatory molecular pathways underlying the cardiovascular diseases associated with SARS-CoV-2 or C. pneumoniae infections. The main therapeutic and preventive approaches using natural antioxidant compounds will be also discussed.
Keyphrases
- sars cov
- oxidative stress
- respiratory syndrome coronavirus
- cardiovascular disease
- reactive oxygen species
- diabetic rats
- ischemia reperfusion injury
- dna damage
- respiratory tract
- induced apoptosis
- coronavirus disease
- cardiovascular risk factors
- signaling pathway
- coronary artery disease
- multidrug resistant
- heat shock protein