Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear-Resultant Quadriceps Atrophy.

Alexander R KeebleCamille R BrightwellChristine M LathamNicholas T ThomasC Brooks MobleyKevin A MurachDarren L JohnsonBrian NoehrenChristopher S Fry

Published in: The American journal of sports medicine (2022)

These findings suggest that blunted protein anabolism as opposed to increased catabolism likely mediates quadriceps atrophy after ACL injury. Thus, future interventions should aim to restore muscle protein anabolism rapidly after ACLT.

Keyphrases

protein protein
physical activity
amino acid
binding protein
skeletal muscle
anterior cruciate ligament reconstruction
small molecule
anterior cruciate ligament