The effect of targeted therapy on recruited cancer stem cells in a head and neck carcinoma model.
Loredana G MarcuDavid MarcuPublished in: Cell proliferation (2017)
The model shows that ATRA exhibits a powerful effect on CSCs when combined with radiotherapy. However, the more radioresistant quiescent cell population should not be ignored, as it can be a potential threat to treatment outcome when cells are recruited into the cell cycle.