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A surrogate molecular approach for the detection of Philadelphia chromosome-like B-acute lymphoblastic leukemia.

Dikshat Gopal GuptaNeelam VarmaSarki Abba AbdulkadirSreejesh SreedharanunniMan Updesh Singh SachdevaShano NaseemParveen BoseJogeshwar BinotaPankaj MalhotraAlka KhadwalAmita TrehanSubhash Varma
Published in: Cancer (2023)
B-acute lymphoblastic leukemia (B-ALL) cases using multiplex-reverse transcriptase polymerase chain reaction. Identification and characterization of Philadelphia (Ph)-like ALL cases using nCounter NanoString gene expression profiling and fluorescence in situ hybridization. Furthermore, Ph-like ALL cases were characterized according to CRLF2 expression and kinase-activating genomic alterations. Minimal residual disease of Ph-like ALL cases were quantified using flow cytometry-minimal residual disease assay. A surrogate molecular approach was established to detect Ph-like ALL cases from low- and middle-income countries.
Keyphrases
  • acute lymphoblastic leukemia
  • flow cytometry
  • copy number
  • genome wide
  • single molecule
  • high throughput
  • acute myeloid leukemia
  • transcription factor
  • binding protein
  • label free