Relation of Life's Essential 8 to the Genetic Predisposition for Cardiovascular Outcomes and All-cause Mortality: Results from a National Prospective Cohort.

Ideal CVH was associated with lower risks of cardiovascular outcomes and all-cause mortality, with a more pronounced association observed in individuals with high PRS for CVD. Improving CVH according to LE8 guidelines should be encouraged, especially for those with PRS that indicate high CVD risk.