Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis.

Silke GastineChristina ObieroZoe KanePhoebe WilliamsJohn ReadmanSheila MurungaJohnstone ThitiriSally EllisErika CorreiaBorna NyaokeKarin KipperJohn van den AnkerMike SharlandJames A BerkleyJoseph F Standing

Published in: The Journal of antimicrobial chemotherapy (2022)

PKPD simulations showed ampicillin and gentamicin combination therapy was insufficient to cover Enterobacterales, suggesting the need for alternative empirical treatment options for neonatal sepsis.

Keyphrases

combination therapy
acute kidney injury
septic shock
intensive care unit
molecular dynamics