Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study.
Kenji FujiyoshiTomoya SudoFumihiko FujitaAkiko ChinoKiwamu AkagiAkinari TakaoMasayoshi YamadaKohji TanakayaHideyuki IshidaKoji KomoriSoichiro IshiharaMasashi MiguchiKeiji HirataYasuyuki MiyakuraToshiaki IshikawaTatsuro YamaguchiNaohiro TomitaYoichi AjiokaKenichi SugiharaPublished in: International journal of clinical oncology (2022)
Alcohol consumption was associated with earlier onset of the first CRC in Japanese LS cohort. The association was stronger in men, carriers of pathogenic MLH1 and MSH2 mutations, and tumors located in the proximal colon. Our findings illuminate the mechanism of LS-associated carcinogenesis and serve as a recommendation for discontinuing or ceasing alcohol consumption.