Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology.

Peter NambalaHarry NoyesJoyce NamulondoOscar NyangiriVincent Pius AlibuBarbara NerimaAnnette MacLeodEnock MatovuJanelisa MusayaJulius Mulindwanull null

Published in: PLoS neglected tropical diseases (2024)

Our results suggest that the differences in disease presentation in the two foci is mainly driven by genetic differences in the parasites in the two major endemic foci of Rumphi and Nkhotakota rather than differences in the environment or host response.

Keyphrases

genome wide
copy number
single cell
dna methylation
gene expression