Sex Differences in Associations Between CYP2D6 Phenotypes and Response to Opioid Analgesics.

Guilherme S LopesSuzette J BielinskiAnn M MoyerJohn Logan Black IiiDebra J JacobsonRuoxiang JiangNicholas B LarsonJennifer L St Sauver

Published in: Pharmacogenomics and personalized medicine (2020)

We replicated and extended the findings of previous research indicating associations between CYP2D6 phenotypes and response to opioids. In addition, the observed associations were stronger in women than in men. We recommend sex differences to be factored in future research investigating associations between pharmacogenomics and response to medications.

Keyphrases

chronic pain
pain management
polycystic ovary syndrome
current status
clinical decision support
emergency department
cervical cancer screening
metabolic syndrome
breast cancer risk
insulin resistance
skeletal muscle
electronic health record