Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway.
Xingchen LiGuidong ChenFanchen WangXiaojing GuoRui ZhangPengpeng LiuLi DongWenwen YuHuan WangHailong WangJinpu YuPublished in: Clinical and translational medicine (2023)
can induce immune evasion by recruiting MDSCs through the 5-LOX-dependent AA pathway, and combination targeted therapy with ICB may provide a promising treatment option for refractory advanced LBC patients.