Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway.

Xingchen LiGuidong ChenFanchen WangXiaojing GuoRui ZhangPengpeng LiuLi DongWenwen YuHuan WangHailong WangJinpu Yu

Published in: Clinical and translational medicine (2023)

can induce immune evasion by recruiting MDSCs through the 5-LOX-dependent AA pathway, and combination targeted therapy with ICB may provide a promising treatment option for refractory advanced LBC patients.

Keyphrases

end stage renal disease
induced apoptosis
chronic kidney disease
newly diagnosed
ejection fraction
stem cells
prognostic factors
transcription factor
cell cycle arrest
oxidative stress
signaling pathway
cell proliferation
cell death
combination therapy
breast cancer risk