Community-Acquired Solitary Brain Abscesses Caused by Hypervirulent Klebsiella pneumoniae in a Healthy Adult.
Joo-Hee HwangJung Soo ParkTae Won BaeJeong-Hwan HwangJaehyeon LeePublished in: Microorganisms (2024)
A 42-year-old man was admitted to the emergency room complaining of fever and headache. His cerebrospinal fluid showed a cloudy appearance, and his white blood cell count was elevated at 2460/mm 3 , with a predominance of neutrophils (81%), and abnormal protein and glucose levels (510.7 mg/dL and 5 mg/dL, respectively). A lobulated lesion with rim enhancement, suggestive of abscess, was detected through magnetic resonance imaging. Klebsiella pneumoniae was detected in nasopharyngeal swab and blood cultures. The capsular serotype of K. pneumoniae was K2 and the sequence type determined by multilocus sequence typing was 23. The hypervirulent phenotype was associated with multiple virulent genes, including rmpA , rmpA2 , entB , ybtS , kfu , iucA , iutA , iroB mrkD , allS , peg-344 , peg-589 , and peg-1631 . After six weeks of receiving appropriate antibiotics and exhibiting clinical resolution of the brain abscesses, the patient was discharged. We present the first reported case of a healthy community-dwelling adult with solitary brain abscesses, and no other invasive abscesses, related to hypervirulent K. pneumoniae .
Keyphrases
- klebsiella pneumoniae
- multidrug resistant
- escherichia coli
- resting state
- magnetic resonance imaging
- white matter
- community dwelling
- drug delivery
- cerebrospinal fluid
- functional connectivity
- healthcare
- cerebral ischemia
- public health
- mental health
- emergency department
- single cell
- cell therapy
- gene expression
- rare case
- multiple sclerosis
- type diabetes
- case report
- genome wide
- stem cells
- metabolic syndrome
- single molecule
- zika virus
- respiratory tract
- contrast enhanced
- blood brain barrier
- adipose tissue
- mesenchymal stem cells
- skeletal muscle
- bone marrow
- drug induced
- genetic diversity