SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model.

Na Yun LeeYoun Woo LeeSeung-Min HongDain OnGyeong Min YoonSee-He AnKi Taek NamJun-Young SeoJeon-Soo ShinYang-Kyu ChoiSeung Hyun OhJun-Won YunHo Young LeeKang-Seuk ChoiJe Kyung SeongJun Won Park

Published in: Laboratory animal research (2023)

Lethal conditions, such as severe body weight loss and encephalopathy, can occur in Omicron-infected K18-hACE2 mice. Our study reports, for the first time, that Omicron can induce brain infection with lymphoid depletion in the mouse COVID-19 model.

Keyphrases

sars cov
coronavirus disease
weight loss
respiratory syndrome coronavirus
resting state
white matter
early onset
bariatric surgery
functional connectivity
type diabetes
emergency department
metabolic syndrome
electronic health record
insulin resistance
adipose tissue
glycemic control