Investigations of Ni(II)Cysteine-Tyrosine Dithiocarbamate Complex: Synthesis, Characterization, Molecular Docking, Molecular Dynamic, and Anticancer Activity on MCF-7 Breast Cancer Cell Line.
Eka PratiwiIndah RayaHasnah NatsirRizal IrfandiPaulina TabaRugaiyah ArfahHerlina RasyidYusafir HalaSyahruddin KasimAndi Besse KhaerunnisaBaso IlhamMaulida MazayaYosua TanzilDewi LuthfianaPublished in: Asian Pacific journal of cancer prevention : APJCP (2024)
there were 5 residues responsible for maintaining the ligand binding stable. The compound had significant Hbond contact intensity, however, it was not strong enough to make a significant anticancer effect. Though the synthesized compound shows low bioactivity, this research is expected to give valuable insight into the effect of molecular structure on anticancer activity.