Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells.

Jeong-Mi KimJung-Han LeeGuem-San LeeEun-Mi NohHyun-Kyung SongDong Ryun GuSeong-Cheol KimSeoung Hoon LeeKang-Beom KwonYoung-Rae Lee

Published in: BMC complementary and alternative medicine (2017)

SFE attenuated the RANKL-mediated induction of NF-κB through inhibition of IκBα phosphorylation, which contributed to inhibiting of RANKL-induced osteoclast differentiation through downregulation of NFATc1.

Keyphrases

signaling pathway
bone loss
nuclear factor
bone marrow
induced apoptosis
oxidative stress
diabetic rats
high glucose
pi k akt
lps induced
drug induced
cell cycle arrest
cell proliferation
toll like receptor
inflammatory response
cell death
protein kinase