Tolerance to high-internalizing δ opioid receptor agonist is critically mediated by arrestin 2.
Ana Vicente-SanchezIsaac J DrippsAlycia F TiptonHeba AkbariAreeb AkbariEmily M JutkiewiczAmynah Amir Ali PradhanPublished in: British journal of pharmacology (2018)
Overall, these results suggest that δ receptor agonists interact with arrestins in a ligand-specific manner, and tolerance to high- but not low-internalizing agonists are preferentially regulated by arrestin 2.
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