The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis.
James S McLayThomas EngelhardtBaba S MohammedGary CameronMindy N CohenJeffrey L GalinkinUwe ChristiansMichael J AvramThomas K HenthornRichard M DsidaAhmed F HawwaBrian Joseph AndersonPublished in: Paediatric anaesthesia (2017)
Clearance, expressed as L. h-1. kg-1 , decreased with age from infancy. A dosing regimen of 0.5 mg. kg-1 every 6 hours maintains a trough concentration larger than 0.37 mg. L-1 in children 9 months to 16 years of age. This dosing regimen is consistent with current recommendations.
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