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Isavuconazole as prophylaxis and therapy for invasive fungal diseases: a real-life observational study.

Mehmet ErgünAnouk M E JansenLuuk B HilbrandsElizabeth A de KortHenricus KunstMonique H E ReijersJeroen A SchoutenPaul E VerweijRoger J M Brüggemann
Published in: The Journal of antimicrobial chemotherapy (2024)
This overview provides practical insights that can aid clinicians in the management of their patients with IFD. Our study shows that isavuconazole was used in a diverse patient population and was well tolerated overall. Individual isavuconazole exposure reflected by the average AUC24 over the first 7 days of treatment was generally low and variable. Dosage adjustments following TDM were frequently performed. Our experience shows that isavuconazole is a feasible alternative after prior azole treatment.
Keyphrases
  • palliative care
  • replacement therapy