Association of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease and retinopathy in type 2 diabetes.
Ernesto MaddaloniLucia CoraggioRocco AmendolaraMarco G BaroniMaria Gisella CavalloMassimiliano CopettiEfisio CossuPaola D'AngeloLuca D'OnofrioSalvatore De CosmoFrida LeonettiSusanna MoranoLelio MorviducciNicola NapoliSabrina PrudenteGiuseppe PuglieseKyoungmin ParkRury R HolmanVincenzo TrischittaRaffaella Buzzettinull nullPublished in: Diabetes/metabolism research and reviews (2023)
In T2D, higher serum osteocalcin concentrations are associated with macrovascular complications and higher osteoprotegerin and osteopontin concentrations with microvascular complications, suggesting that these osteokines might be involved in pathways directly related to vascular disease.