Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium.

Wanping ZhangEmmanuel A Bazan-BergaminoAnton P DoanXiangjun ZhangLyle D Isaacs

Published in: Chemical communications (Cambridge, England) (2024)

The binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1 H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio.

Keyphrases

mass spectrometry
ms ms
angiotensin converting enzyme
high speed
capillary electrophoresis
binding protein
dna binding
nucleic acid