Genetic Deficiency of Interferon-γ Reveals Interferon-γ-Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis.

Thomas N BurnLehn WeaverJulia E RoodNiansheng ChuAaron BodanskyPortia A KreigerEdward M Behrens

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

IFNγ is not necessary for the development of fulminant HLH, requiring physicians to consider case-by-case treatment strategies. Use of therapies that target upstream activators of CD8+ T cells, such as IL-33/ST2 signaling, may be more universally applicable treatment options that ameliorate both IFNγ-dependent and -independent manifestations of HLH/MAS.

Keyphrases

dendritic cells
immune response
primary care
copy number
hepatitis b virus
dna methylation
smoking cessation