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Genetic Deficiency of Interferon-γ Reveals Interferon-γ-Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis.

Thomas N BurnLehn WeaverJulia E RoodNiansheng ChuAaron BodanskyPortia A KreigerEdward M Behrens
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
IFNγ is not necessary for the development of fulminant HLH, requiring physicians to consider case-by-case treatment strategies. Use of therapies that target upstream activators of CD8+ T cells, such as IL-33/ST2 signaling, may be more universally applicable treatment options that ameliorate both IFNγ-dependent and -independent manifestations of HLH/MAS.
Keyphrases
  • dendritic cells
  • immune response
  • primary care
  • copy number
  • hepatitis b virus
  • dna methylation
  • smoking cessation