Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway.

Yuan-Chun YueBao-Yu YangJing LuShu-Wen ZhangLiu LiuKhaled NassarXiao-Xi XuXiao-Yang PangJia-Ping Lv

Published in: Microbial cell factories (2020)

Our results showed that metabolite secretions of YYC-3 may inhibited cell metastasis by downregulating the VEGF/MMPs signaling pathway. These data suggest that treatment of CRC cells with metabolites from L. plantarum YYC-3 may reduce colon cancer metastasis.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
vascular endothelial growth factor
endothelial cells
cell cycle arrest
epithelial mesenchymal transition
single cell
ms ms
stem cells
cell therapy
big data
cell proliferation
deep learning
data analysis