Serum levels of leptin, osteopontin, and sclerostin in patients with and without knee osteoarthritis.

Our study of 249 serum samples was conducted. Serum leptin, OPN, and SOST were significantly increased in KOA patients, and there was an internal correlation; these findings could, at best, contribute to the identification of novel targets for medical interventions. Key Points • The aim of this study was to assess the relationships of radiographic knee OA with altered serum levels of leptin, OPN, and SOST. Our study of 249 serum samples was conducted. Serum leptin, OPN, and SOST were significantly increased in KOA patients compared with control group. There were gender differences in the concentration of three serum bone turnover factors in KOA group and control group. Serum SOST concentration increased with Kellgren-Lawrence (K-L) grading. We found that serum leptin, OPN, and SOST were significantly increased in KOA patients, and there was an internal correlation. Leptin had a remarkable diagnostic value in the incidence of KOA.