SHP2 inhibition attenuates osteoarthritis by maintaining homeostasis of cartilage metabolism via the DOK1/UPP1/uridine cascade.

Qianqian LiuLinhui ZhaiMingrui HanDongquan ShiZiying SunShuang PengMeijing WangChenyang ZhangJian GaoWenjin YanQing JiangDijun ChenQiang XuMinjia TanYang Sun

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

SHP2 is a novel accelerator of the imbalance in the cartilage homeostasis. Specific inhibition of SHP2 may ameliorate OA by maintaining the anabolic and catabolic balance.

Keyphrases

knee osteoarthritis
extracellular matrix
rheumatoid arthritis