A natural diarylheptanoid protects cortical neurons against oxygen-glucose deprivation-induced autophagy and apoptosis.

Qiaoyun ShiQinghua ZhangYinghui PengXiaoqi ZhangYing WangLei Shi

Published in: The Journal of pharmacy and pharmacology (2019)

These results demonstrate that AO-2 increases resistance of cortical neurons to OGD/R by decreasing autophagy and cell apoptosis, which involves an mTOR-dependent mechanism.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
diabetic rats
spinal cord
cell proliferation
cell cycle arrest
signaling pathway
high glucose
drug induced
metabolic syndrome
skeletal muscle
spinal cord injury