Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor β (TGFβ) signaling.
Terese KarlssonReshma SundarAnders WidmarkMaréne LandströmEmma PerssonPublished in: The Prostate (2018)
These findings suggests that factors secreted from osteoblasts, including TGFβ, can induce several cellular traits involved in metastatic potential of PC-3U cells, further strengthening the role for bone cells to promote metastatic tumor cell behavior.
Keyphrases
- transforming growth factor
- induced apoptosis
- squamous cell carcinoma
- epithelial mesenchymal transition
- small cell lung cancer
- cell cycle arrest
- endothelial cells
- endoplasmic reticulum stress
- signaling pathway
- single cell
- cell death
- gene expression
- dna methylation
- risk assessment
- climate change
- genome wide
- human health
- mesenchymal stem cells
- induced pluripotent stem cells