Tonic, Burst, and Burst Cycle Spinal Cord Stimulation Lead to Differential Brain Activation Patterns as Detected by Functional Magnetic Resonance Imaging.

Mohammad SaberDavid SchwabeHyun-Joo ParkJohn TessmerZan KhanYujie DingMaraika RobinsonQuinn H HoganChristopher P Pawela

Published in: Neuromodulation : journal of the International Neuromodulation Society (2021)

The high-resolution fMRI study using rat model demonstrated the potential of different SCS modes to act on several pain-matrix related regions of the brain in response to noxious stimulation. The burst and burst-cycle SCS exhibited greater brain activity reduction in response to noxious hindlimb stimulation in caudate putamen, insula, and secondary somatosensory cortex compared to tonic stimulation.

Keyphrases

resting state
functional connectivity
high frequency
magnetic resonance imaging
spinal cord
high resolution
white matter
neuropathic pain
chronic pain
mass spectrometry
risk assessment
working memory
human health
contrast enhanced