Monocytes as Potential Mediators of Pathogen-Induced T-Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC).
Lilly Kristin KunzmannTanja SchoknechtTobias PochLara HenzeStephanie SteinMarvin KrizIlka GreweMax PretiJohannes HartlNadine PannickeMoritz PeiselerMarcial SebodeRoman ZenouziThomas HorvatitsMarius BöttcherBritt-Sabina PetersenChristina Weiler-NormannLeonard U HessAnnika Elise AhrenstorfSebastian LunemannGloria MartrusLutz FischerJun LiAntonella CarambiaJohannes KluweSamuel HuberAnsgar W LohseAndre FrankeJohannes HerkelChristoph SchrammDorothee SchwingePublished in: Hepatology (Baltimore, Md.) (2020)
PSC patients show increased Th17 differentiation already in vivo. Microbe-stimulated monocytes drive Th17 differentiation in vitro and induce cholangiocytes to produce chemokines mediating recruitment of Th17 cells and more monocytes into portal tracts. Taken together, these results point to a pathogenic role of monocytes in patients with PSC.