Acute kidney injury after CAR-T cell therapy: exploring clinical patterns, management, and outcomes.
Maud VincendeauAdrien JosephCatherine ThieblemontFlorence RabianStéphanie HarelSandrine ValadeLara ZafraniPublished in: Clinical kidney journal (2024)
AKI may occur in ICU patients receiving CAR-T cell therapy, especially those who experience CRS and exhibit elevated LDH levels. Early recognition of AKI is of utmost importance as it substantially compromises survival in these patients. Future studies should aim to elucidate the underlying pathophysiological mechanisms of AKI in this context and pinpoint predictive factors for long-term risks of CKD.
Keyphrases
- cell therapy
- acute kidney injury
- cardiac surgery
- end stage renal disease
- stem cells
- mesenchymal stem cells
- chronic kidney disease
- ejection fraction
- intensive care unit
- peritoneal dialysis
- prognostic factors
- mechanical ventilation
- current status
- climate change
- skeletal muscle
- bone marrow
- metabolic syndrome
- acute respiratory distress syndrome
- case control