A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats.

Marina KomrakovaG BüchlerK O BökerW LehmannA F SchillingP J RochS TaudienD B HoffmannS Sehmisch

Published in: Journal of endocrinological investigation (2022)

The EN + RAL treatment appeared to be promising in preventing male osteoporosis, but given the observed side effects on liver, kidney, and prostate weights, it requires further investigation.

Keyphrases

estrogen receptor
bone loss
prostate cancer
small molecule
postmenopausal women
mouse model
replacement therapy