The field of organ transplantation has been facing the problem of organ shortage for several years. It is even more crucial since the number of patients on the waiting list is growing steadily. There have been numerous approaches to resolve the issue: on the one hand, extending the donation criteria and, on the other hand, improving organ preservation using machine perfusion. Experimental and clinical studies have already proven that machine perfusion decreases the incidence of delayed graft function and improves graft survival, which is particularly significant in extended criteria donation. Machine perfusion is used widely in kidney transplantation. The most frequently used method is hypothermic machine perfusion but the normothermic method is gaining more attention as well. Depending on the temperature set, machine perfusion may not only be used for organ preservation but also for organ conditioning. There is still ongoing research in the field of therapeutic approaches during machine perfusion, which may play an important role in decreasing ischaemia-reperfusion injury and immunogenicity in grafts. After a brief description of extended criteria donation, our review aims to summarize the methods and the latest results of machine perfusion, including diagnostic and therapeutic approaches in the field of kidney transplantation. Orv Hetil. 2023; 164(9): 339-347.
Keyphrases
- kidney transplantation
- deep learning
- contrast enhanced
- end stage renal disease
- chronic kidney disease
- magnetic resonance imaging
- heart failure
- magnetic resonance
- machine learning
- computed tomography
- stem cells
- bone marrow
- ejection fraction
- acute coronary syndrome
- brain injury
- mesenchymal stem cells
- left ventricular
- cell therapy
- acute ischemic stroke
- subarachnoid hemorrhage
- patient reported