Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R BadenHana M El SahlyBrandon EssinkKaren KotloffSharon FreyRick NovakDavid DiemertStephen A SpectorNadine RouphaelC Buddy CreechJohn McGettiganShishir KhetanNathan SegallJoel SolisAdam BroszCarlos FierroHoward SchwartzKathleen NeuzilLawrence CoreyPeter GilbertHolly JanesDean FollmannMary MarovichJohn MascolaLaura PolakowskiJulie LedgerwoodBarney S GrahamHamilton BennettRolando PajonConor KnightlyBrett LeavWeiping DengHonghong ZhouShu HanMelanie IvarssonJacqueline MillerTal Zaksnull nullPublished in: The New England journal of medicine (2020)
The mRNA-1273 vaccine showed 94.1% efficacy at preventing Covid-19 illness, including severe disease. Aside from transient local and systemic reactions, no safety concerns were identified. (Funded by the Biomedical Advanced Research and Development Authority and the National Institute of Allergy and Infectious Diseases; COVE ClinicalTrials.gov number, NCT04470427.).