Repetitive Transcranial Magnetic Stimulation Delivered With an H-Coil to the Right Insula Reduces Functional Connectivity Between Insula and Medial Prefrontal Cortex.
Mary R LeeElisabeth C CaparelliMichelle LeffVaughn R SteeleAndrea M MaxwellKaren McCulloughBetty Jo SalmeronPublished in: Neuromodulation : journal of the International Neuromodulation Society (2019)
There was no effect of rTMS, regardless of frequency, on task behavior or task-based BOLD response. There was an effect of rTMS compared to sham on rsFC between insula and medial prefrontal cortex, with connectivity reduced after rTMS compared to sham, regardless of frequency. Implications for using rTMS to the insula as a treatment for neuropsychiatric disorders are discussed in light of insula-medial prefrontal cortex connectivity.