Login / Signup

Electrochemically Synthesized Polyacrylamide Gel and Core-Shell Nanoparticles for 3D Cell Culture Formation.

Nabila YasmeenAneta KarpińskaJakub KaleckiWlodzinierz KutnerKarina KwapiszewskaPiyush Sindhu Sharma
Published in: ACS applied materials & interfaces (2022)
Biocompatible polyacrylamide gel and core-shell nanoparticles (NPs) were synthesized using a one-step electrochemically initiated gelation. Constant-potential electrochemical decomposing of ammonium persulfate initiated the copolymerization of N -isopropyl acrylamide, methacrylic acid, and N , N '-methylenebisacrylamide monomers. This decomposing potential and monomers' concentrations were optimized to prepare gel NPs and thin gel film-grafted core-shell NPs. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) imaging confirmed the gel NP formation. The lyophilized gel NPs and core-shell NPs were applied to support the three-dimensional (3D) cell culture. In all, core-shell NPs provided superior support for complex 3D tissue structures.
Keyphrases
  • electron microscopy
  • oxide nanoparticles
  • wound healing
  • high resolution
  • hyaluronic acid
  • ionic liquid
  • gold nanoparticles
  • climate change
  • walled carbon nanotubes
  • label free