Protective effect of α7 nicotinic acetylcholine receptor activation on experimental colitis and its mechanism.

Wenyuan PuZhenzi SuJunaid WazirChen ZhaoLulu WeiRanran WangQiyi ChenSaifang ZhengShaoyi ZhangHongwei Wang

Published in: Molecular medicine (Cambridge, Mass.) (2022)

Thus, an α7nAChR agonist ameliorated colonic pathology and inflammation in DSS-induced colitis mice by blocking the activation of inflammatory M1 macrophages.

Keyphrases

oxidative stress
ulcerative colitis
high fat diet induced
skeletal muscle