Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis.
Joshua P SasineNatalia Y KozlovaLisa ValicenteJennifer DukovDana H TranHeather A HimburgSanjeev KumarSarah KhorsandiAldi ChanSamantha GroheMichelle LiJenny KanMary E SehlGary J SchillerBryanna ReinhardtBrijesh Kumar SinghRitchie HoPeibin YueElena B PasqualeJohn P ChutePublished in: Cancer research (2024)
Ephrin B2 reverse signaling mediated by endothelial cells directly regulates multiple myeloma progression and treatment resistance, which can be overcome through targeted inhibition of ephrin B2 to abolish myeloma.