Activation of Toll-like receptor 4 by thyroid hormone triggers abnormal B-cell activation.
Jie WangGuo-Qing LiShu LiuJing-Jing MiaoQi SunWen-Sha GuXiao-Ming MaoPublished in: Immunity, inflammation and disease (2023)
The present study indicated that high levels of T3 can induce abnormal differentiation and activation of B cells by promoting TLR4 overexpression and provide novel insights into the roles of THs in the pathogenesis of GD.