The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI.
Jostein NordengHossein SchandizSvein SolheimSissel ÅkraPavel HoffmannBorghild RoaldBjørn BendzHarald ArnesenRagnhild HelsethIngebjørg SeljeflotPublished in: Mediators of inflammation (2021)
The inflammasome signaling pathway was actively regulated in coronary thrombi and in circulating leukocytes from patients with STEMI, in association with myocardial damage measured by troponin T. This supports the strategy of medically targeting this pathway in treating myocardial infarction and contributes to sort out optimal timing and targets for anti-inflammatory treatment. The study is registered at clinicaltrials.gov with identification number NCT02746822.
Keyphrases
- signaling pathway
- left ventricular
- coronary artery disease
- coronary artery
- percutaneous coronary intervention
- pi k akt
- anti inflammatory
- oxidative stress
- transcription factor
- st elevation myocardial infarction
- st segment elevation myocardial infarction
- epithelial mesenchymal transition
- aortic stenosis
- heart failure
- induced apoptosis
- cancer therapy
- acute coronary syndrome
- combination therapy
- aortic valve
- atrial fibrillation
- bioinformatics analysis
- transcatheter aortic valve replacement