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Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma.

Hirohito IshigakiTakayoshi YamauchiMark D LongToshifumi HokiYuta YamamotoTakaaki ObaFumito Ito
Published in: Cancer research communications (2024)
Intratumoral T cells are composed of heterogeneous subpopulations with various phenotypic and transcriptional states. This study illustrates the intratumoral generation of antigen-specific CX3CR1+ CD8+ T cells that exhibit distinct transcriptomic signatures and clinical relevance from CD8+ T cells expressing markers of exhaustion.
Keyphrases
  • single cell
  • rna seq
  • gene expression
  • transcription factor
  • genome wide
  • dna methylation
  • heat shock
  • skin cancer