Inactivation of soluble guanylyl cyclase in living cells proceeds without loss of haem and involves heterodimer dissociation as a common step.
Yue DaiDennis J StuehrPublished in: British journal of pharmacology (2021)
Oxidative (ODQ) or nitrosative (NOC12) inactivation of cell sGC involves sGC heterodimer dissociation and rearrangement of the sGCβ protein partners without any haem loss from sGCβ. Clarifying what changes do and do not occur to sGC during its inactivation in cells may direct strategies to preserve or recover NO-dependent cGMP signalling in health and disease.
Keyphrases
- living cells
- fluorescent probe
- induced apoptosis
- healthcare
- single molecule
- nitric oxide
- cell cycle arrest
- mental health
- cell therapy
- stem cells
- health information
- signaling pathway
- electron transfer
- endoplasmic reticulum stress
- bone marrow
- amino acid
- hepatitis c virus
- human immunodeficiency virus
- protein protein
- pi k akt