Molecular mechanisms underpinning favourable physiological adaptations to exercise prehabilitation for urological cancer surgery.
James E M BlackwellNima GharahdaghiColleen S DeaneMatthew S BrookJohn P WilliamsJonathan N LundPhilip J AthertonKenneth SmithDaniel J WilkinsonBethan E PhillipsPublished in: Prostate cancer and prostatic diseases (2023)
A HIIT surgical prehabilitation regime, which improved the CRF of urological cancer patients, enhanced capacity for skeletal muscle OXPHOS; offering potential mechanistic explanation for this favourable adaptation. HIIT did not stimulate MPS, synonymous with the observed lack of hypertrophy. Larger trials pairing patient-centred and clinical endpoints with mechanistic investigations are required to determine the broader impacts of HIIT prehabilitation in this cohort, and to inform on future optimisation (i.e., to increase muscle mass).
Keyphrases
- high intensity
- skeletal muscle
- resistance training
- minimally invasive
- papillary thyroid
- coronary artery bypass
- urinary tract
- insulin resistance
- case report
- current status
- type diabetes
- human health
- lymph node metastasis
- coronary artery disease
- adipose tissue
- young adults
- body composition
- acute coronary syndrome
- atrial fibrillation
- percutaneous coronary intervention